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Eine Vielzahl von Betroffenen entwickelt DP-Symptome nach Cannabis oder Ecstasy Gebrauch.
Aber auch beim Absetzen von verschiedenen Medikamenten (insbesondere Benzodiazepine oder Antidepressiva) kann es zum Auftreten von DP oder DR kommen.
Drogen:
Cannabis: akute Cannabinoidintoxikation (Forschungskriterien)
ForschungskriterienActa Psychiatr Scand 1999 Jul;100(1):67-75 Regional cerebral blood flow and depersonalization after tetrahydrocannabinol administration.
Mathew RJ, Wilson WH, Chiu NY, Turkington TG, Degrado TR, Coleman RE. Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA.OBJECTIVE: The aim of this study was to examine the relationship between depersonalization induced by tetrahydrocannabinol (THC), and regional brain activation. METHOD: Cerebral blood flow (CBF) was measured by means of positron emission tomography (PET) in 59 normal right-handed volunteers before and following intravenous infusions of THC. RESULTS: After THC, CBF showed a global increase which was more marked in the right hemisphere, frontal lobes and anterior cingulate. CONCLUSION: Regression analyses showed positive correlations between the right frontal and anterior cingulate and depersonalization.
Biol Psychiatry 1993 Mar 15;33(6):431-41 Depersonalization after marijuana smoking. Mathew RJ, Wilson WH, Humphreys D, Lowe JV, Weithe KE.
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710.
Depersonalization and other behavioral and physiological indices were monitored before and after the administration of high- and low-potency marijuana cigarettes and a placebo cigarette in 35 physically and mentally healthy normal volunteers. The cigarettes were administered under double-blind conditions during three visits to the laboratory separated by a minimum of 1 week. Marijuana smoking, but not placebo smoking, was associated with significant depersonalization that was maximal 30 min after smoking the high-potency cigarettes. Other behavioral changes induced by marijuana included disintegration of time sense, sensation of "high," increased state anxiety, tension, anger, and confusion. Respiration, pulse rate, and systolic blood pressure also increased after marijuana smoking. Multiple regression identified temporal disintegration as the most significant predictor of depersonalization.
Ecstasy: DP nach Ecstasy Gebrauch (Artikel von K. Jansen) Karl Jansen
Abstract:
Nervenarzt 1993 Jul;64(7):478-80 Related Articles, Books
Comment in: Nervenarzt. 1994 Sep;65(9):648-50.
["Ecstasy"-induced psychotic depersonalization syndrome]
[Article in German]
Wodarz N, Boning J. Psychiatrische Klinik und Poliklinik, Universitat Wurzburg.
The 'designer drug' 3,4-methylenedioxy-metamphetamine (MDMA; 'Ecstasy'), which has become increasingly popular in the past few years, is supposed to induce a feeling of euphoria with amphetamine-like stimulant effects. It was for some time considered harmless, but neurotoxic effects on serotonergic neurons are now well documented. To supplement case reports on different drug-induced psychopathological and somatic complications published in recent literature, the case of a 21-year-old female patient is reported, who exhibited a protracted psychotic depersonalization disorder with suicidal tendency after the first intake of two tablets of "ecstasy". In the course of six
months the symptoms remitted only gradually despite administration of a serotonin re-uptake inhibitor, 'flash-backs' occurring repeatedly.
Anaesth Intensive Care 2002 Jun;30(3):382-4 Ketamine dependence. Pal HR, Berry N, Kumar R, Ray R. De-addiction Centre, All India Institute of Medical Sciences, New Delhi.
Ketamine hydrochloride is a safe and rapid-acting non-opioid, lipid soluble anaesthetic with a short elimination half-life that is used for medical and veterinary purposes. It produces a state of "dissociative anaesthesia", probably from action on N-methyl-D-aspartate (NMDA) receptors. The psychotropic effects of ketamine range from dissociation and depersonalization to psychotic experiences and include a sensation of feeling light, body distortion, absence of time sense, novel experiences of cosmic oneness and out-of-body experiences. Abuse of ketamine has been reported, the typical abuser being an individual who uses multiple drugs and has some contact with medical agencies. This case demonstrates the effects of large doses of ketamine in a person with polysubstance abuse. The case also highlights development of significant tolerance to ketamine without prominent withdrawal symptoms. Caution in use of ketamine is reiterated in light of its abuse liability.
LSD: Vergleich psychotischer Symptome und nach LSD Gebrauch LSD und Psychose
Medikamente:
Benzodiazepine: Benzodiazepine
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